Dihexa / Tesofensine.
A combination cognitive-and-metabolic protocol — appetite control and brain support in one oral capsule.
5 mg / 500 mcg · oral capsulePricing is shown after your free assessment, before you commit.
Free to start. No card required.
Reviewed by Lumora clinical team (Licensed provider network)Mixed evidenceSource: Client-approved product catalog; provider review required
Evidence, regulatory status, and fit vary by medication, formulation, route, and individual history.
Is this for you?
This is for you if
- Adults pursuing physician-supervised weight loss with cognitive demands (work, school, performance)
- Patients who have not responded to other appetite-modulating therapies
- Patients under specialist supervision with appropriate baseline labs
This isn't for you if
Highly investigational. Tesofensine carries cardiovascular and psychiatric monitoring requirements: elevated heart rate, blood pressure, insomnia, and mood changes are possible. Not appropriate with cardiovascular disease, psychiatric instability, seizure history, pregnancy, breastfeeding, or with other stimulant or serotonergic medications. Specialist supervision is required.
Dihexa / Tesofensine
This combination pairs Dihexa, a high-potency cognitive peptide studied for synaptic plasticity, with Tesofensine, a triple monoamine reuptake inhibitor studied for appetite control and weight management. It is one of the most investigational protocols in the catalog and reserved for select, closely supervised cases.
Mechanism and fit.
Tesofensine raises dopamine, serotonin, and norepinephrine signaling — driving appetite reduction, mood elevation, and modest metabolic increase. Dihexa supports synapse formation and neuroplasticity, which may help offset the cognitive disruption that can come with aggressive weight-loss programs. The pairing is studied for patients who want metabolic results without losing cognitive sharpness.
Who this is typically for.
- Adults pursuing physician-supervised weight loss with cognitive demands (work, school, performance)
- Patients who have not responded to other appetite-modulating therapies
- Patients under specialist supervision with appropriate baseline labs
What patients
most often ask.
Why is this prescribed cautiously?
Tesofensine has potent neurochemical effects and limited large-scale human safety data. Combined with Dihexa, the protocol is reserved for patients who genuinely need this approach and can be closely monitored.
Who this is typically for.
These are common fit patterns from the approved catalog. Your provider determines whether treatment is appropriate.
- <ul><li>Adults pursuing physician-supervised weight loss with cognitive demands (work, school, performance)</li><li>Patients who have not responded to other appetite-modulating therapies</li><li>Patients under specialist supervision with appropriate baseline labs</li></ul>
How this option
is evaluated.
The plan is provider-determined after reviewing your assessment and safety factors.
- DosingOnce daily oral, provider-directed.
- Typical durationProvider-directed cycles with close monitoring.
- Safety and eligibilityYour provider reviews contraindications, medication interactions, goals, and safety factors before prescribing.
- A licensed provider reviews your assessment before any treatment is recommended.
- You see full pricing - visit fees, medication, labs, follow-up - before you commit.
- Your plan can be adjusted, paused, or stopped based on response and safety. Your clinician is reachable - not a chatbot.
- Compounded medications are not FDA-approved and are dispensed only when prescribed by a licensed provider.
Start with
provider review.
If you are considering Dihexa / Tesofensine, the first step is a free assessment. A provider determines whether it fits your goals and medical history.
A provider determines whether treatment is clinically appropriate.